DNA secondary structures and epigenetic determinants of cancer genome evolution
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منابع مشابه
DNA secondary structures and epigenetic determinants of cancer genome evolution
950 VOLUME 18 NUMBER 8 AUGUST 2011 NAture StructurAL & moLecuLAr bIoLogY Loss of genomic integrity is a common hallmark of cancer genomes1. Recent technological advances have led to several large-scale cancer genome profiling studies2–5 that have identified genome-wide patterns of alterations in many cancer samples. Notably, DNA breakpoints in cancer genomes, and also in the genomes of apparent...
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DNA secondary structures containing regions of single-stranded DNA have now been identified in the genomic DNA of a number of prokaryotic and eukaryotic species, including humans. Many of these secondary structures are associated with regions of DNA involved in regulation of transcription: promoters or upstream elements. The secondary structures involved appear likely to be hairpin or cruciform...
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DNA sequence information is pivotal to transcription, replication and recombination. DNA structure is dependent upon intracellular conditions such as ion concentration and the presence of proteins that may bind to DNA to facilitate the interconversion between different forms and to stabilize specific secondary structures. Dependent upon the primary DNA sequence, purine- and pyrimidine-rich stra...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2011
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb.2089